Sundaravel Vivek Kumar

Buy Article Permissions and Reprints All articles of this category Asymmetric catalysis constitutes a key strategy for the enantioselective synthesis of natural products and bioactive compounds. Chiral ligands are crucial for achieving the required reactivity and enantioselectivity in asymmetric catalytic reactions. Consequently, the rational design of chiral ligands is central to the development of new asymmetric transition-metal-catalyzed reactions.

Graphical Abstract Pyrrolidines are intriguing scaffolds that can be found in a variety of natural products. They have numerous biological and organocatalytic uses. The asymmetric [3+2] cycloadditions employing metal catalysis with suitable chiral ligands is a robust method for the synthesis of enantioenriched pyrrolidines with up to four chiral centres. Recent advances are summarized in the Review by Guiry and Kumar (DOI. 10.1002/chem.202300296).