Suneel D. Kamath, MD and Vlad G. Zaha, MD, PhD, FACC, FAHA, reviewing Structured exercise significantly reduces recurrence risk and improves survival for stage II and III colon cancer. While outcomes after surgery and adjuvant chemotherapy for stage II/III colon cancer are generally good, cancer still recurs in about 30% of patients, and quality of life and cardiorespiratory fitness are decreased.