Sung Ung Moon

1 Introduction The continuous emergence of new SARS-CoV-2 variants poses a significant challenge in developing globally effective vaccines and achieving sufficient immunization to contain the virus.[1, 2] The Spike protein, which remained the primary target for COVID-19 vaccine development, contains hotspots of mutations within its hypervariable receptor-binding domain (RBD) that are directly involved in both vaccines- and infection-induced immune escape and in host susceptibility.[3] While...

Abstract Unfolded protein response (UPR) is an adaptive mechanism that aims at restoring ER homeostasis under severe environmental stress. Malignant cells are resistant to environmental stress, which is largely due to an activated UPR. However, the molecular mechanisms by which different UPR branches are selectively controlled in tumor cells are not clearly understood.

Theragnosis by MiR-141-3p Molecular Beacon: Simultaneous Detection and Sensitization of 5-Fluorouracil Resistant Colorectal Cancer Cells through the Activation of TRIM13-Associated Apoptotic Pathway 5-Fluorouracil (5-FU)-based chemotherapy is widely used for the treatment of advanced colorectal cancer (CRC). However, chemotherapy often becomes inefficient, due to the chemoresistance of CRC.