Sung Weon Choi

Abstract Growing evidence suggests that lipid metabolic reprogramming occurs in oral cancer (OC). We characterized circulating metabolic alterations associated with lipid metabolic reprogramming in OC. Semi-targeted and targeted plasma metabolomic profiling was performed in a discovery cohort (182 OC, 364 healthy controls [HC]) followed by independent external validation (52 OC, 52 HC).

Abstract : Simple Summary Although there is strong evidence linking oral microbiota to several types of cancer, the causal connections between them remain controversial. This study aims to identify the common oral bacteria associated with various types of cancer and detect potential mechanisms underlying the oral microbiota that could activate immune responses and lead to the onset of cancer through cytokine secretion.