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Suntao Shi

As seen in: ACS Publications
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Articles

Drug Screening of Nitroreductase Modulators Using an Atomic-Engineered Activatable Fluorescent Probe for Tumor Imaging Click to copy article link Article link copied!

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By Suntao Shi, Ruipeng Shen, Liangying Mi
| ACS Publications
Abstract Click to copy section linkSection link copied! Nitroreductase (NTR), a hypoxia-upregulated enzyme, is a promising biomarker for solid tumors, driving demand for effective biosensors. Cyanine dyes are prominent fluorophores widely used in fluorescence imaging, tumor phototheranostics, and image-guided surgery. Guided by atomic engineering through strategic heteroatom substitution (C, O, and S), we designed four NTR-activated probes.
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Tuning Lipophilicity to Develop an MMP-Independent Fluorescent Probe for Visualizing Mitochondrial Peroxynitrite in Drug-Induced Liver Injury

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By Sayed Zahid Nasim, Mengzhao Zhang, Ruipeng Shen, Suntao Shi
| dx.doi.org
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Tuning Lipophilicity to Develop an MMP-Independent Fluorescent Probe for Visualizing Mitochondrial Peroxynitrite in Drug-Induced Liver Injury

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By Sayed Zahid Nasim, Mengzhao Zhang, Suntao Shi, Ruipeng Shen
| ACS Publications
Abstract Click to copy section linkSection link copied! Mitochondrial peroxynitrite (ONOO–), a highly reactive nitrogen species, is critically involved in oxidative-stress-induced cell damage, playing vital roles in the pathogenesis of numerous diseases. However, the real-time detection of ONOO– in mitochondria is still challenging due to the reliance of existing probes on mitochondrial membrane potential (MMP), often disrupted under disease conditions.
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