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Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells
1 INTRODUCTION Dysregulation of cell cycle progression is common in tumorigenesis; it leads to the over‐proliferation of cells. Cyclin‐dependent kinases (CDKs) regulate the cell cycle, and their activity is partially inhibited by CDK inhibitors, including p21 (also known as CDKN1A).
PES1 is a critical component of telomerase assembly and regulates cellular senescence
Abstract Telomerase defers the onset of telomere shortening and cellular senescence by adding telomeric repeat DNA to chromosome ends, and its activation contributes to carcinogenesis. Telomerase minimally consists of the telomerase reverse transcriptase (TERT) and the telomerase RNA (TR). However, how telomerase assembles is largely unknown.
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