Suphagan Boonpethkaew

Abstract Polynucleotide (PN) injectables are increasingly used in aesthetic medicine, making a clear understanding of their intravascular behavior essential. We conducted a controlled animal study using a rabbit central ear artery model to evaluate the cutaneous consequences of intra-arterial PN injection, comparing formulations with differing viscosities (Rejuran S, Rejuran HB Plus, and Conjuran) with normal saline and cross-linked hyaluronic acid (HA).

1 Introduction Acne erythema (AE) is a common concern both during active acne inflammation and after its resolution. It is characterized by erythematous macules or patches, often accompanied by telangiectasia [1]. While AE lesions may gradually improve over time, some persist even after inflammatory acne has resolved. AE is often considered cosmetically undesirable and can lead to significant patient frustration and psychological distress [2].

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description exd70176-sup-0001-Figures.docxWord 2007 document , 2.5 MB Figure S1: An overview of the experimental design. Figure S2: Immunohistochemical staining for immune cell markers.