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Articles

Molecular Systems Biology

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By Xiaolu Guo, Supriya Sen, Julian Gonzalez
| TechTrends
Electronic ISSN 1744-4292 Abstracted and indexed in BIOSIS Baidu Biological Abstracts CLOCKSS CNKI CNPIEC Chemical Abstracts Service (CAS) Chinese Academy of Medical Science (CAMS) Current Contents/Life Sciences DOAJ Dimensions EBSCO EMBASE Google Scholar Japanese Science and Technology Agency (JST) Medline Naver OCLC WorldCat Discovery Service Ovid Discovery Pathway Studio Portico ProQuest PubMedCentral Reaxys SCImago SCOPUS Science Citation Index Expanded (SCIE) TD Net Discovery Service...
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Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions

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By Supriya Sen, Sho Ohta, Quen Cheng, Faraz Behzadi
| Nature Verified
Abstract Macrophages orchestrate immune responses by sensing and responding to pathogen-associated molecules. These responses are modulated by prior conditioning with cytokines such as interferons (IFNs). Type I and II IFN have opposing functions in many biological scenarios, yet macrophages directly stimulated with Type I or II IFN activate highly overlapping gene expression programs.
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