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Surya Pratap S. Deopa on Muck Rack

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Force-Induced Ankle Opening Reveals Mechanical Stabilization of the Ankle of Human β-Cardiac Myosin Click to copy article link Article link copied!

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By Kristen K Bjorkman, Devin T. Edwards, Surya Pratap S. Deopa
| dx.doi.org
Human β-cardiac myosin is the primary molecular motor that drives heart contraction. Mutations in human β-cardiac myosin and other sarcomeric proteins are a major cause of hypertrophic cardiomyopathy (HCM), (1) which affects up to 1 in 500 adults and is the leading cause of sudden death among young adults. (2,3) However, an understanding of the underlying molecular mechanisms of most myosin mutations that cause HCM remains elusive.
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