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Susan E. Howlett on Muck Rack

Susan E. Howlett

As seen in: Nature, Cell Metabolism, Canadian Journal of Cardiology, Alzheimer's & Dementia, Silversurfers
Canadian research scientist at Dalhousie University in Halifax. Exploring the impact of aging, frailty and sex hormones on health, especially heart health.
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Articles

Sodium nitrate supplementation prevents beneficial cardiac adaptations to running in female mice with few effects on male hearts

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By W. Glen Pyle, Scott A. Grandy, Susan E. Howlett, Elise S. Bisset, Gracious D. S. Kasheke
| Nature Verified
Abstract While dietary nitrate supplements combined with aerobic activity are thought to enhance cardiac function, this has not been well investigated, and studies have used male animals only. We provided 7–9-month-old male and female mice with sodium nitrate (1 mM), running wheel access, both, or neither for 12 weeks and measured heart structure/function (echocardiography), contractions/calcium transients (ventricular myocytes), calcium handling genes and myofilament function (ventricles).
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Heart failure

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By Susan E. Howlett
| heartandstroke.ca
Palliative care Some people living with heart failure can benefit from end-of-life care (also called palliative care). It can comfort you and your family. If you want to get more information about end-of-life care, talk to your healthcare providers. You can also visit Public Health Agency of Canada and Health Canada. The Canadian Hospice Palliative Care Association has a directory of end-of-life care services across the country and a caregiver resource list.
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The intersection of frailty and metabolism

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By MANISH MISHRA, Judy Wu, Alice E Kane, Susan E. Howlett
| Cell Metabolism Verified
Roser M. Ortiz-Ospina E. Ritchie H. Life Expectancy. 2013 López-Otín C. Galluzzi L. Freije J.M.P. Madeo F. Kroemer G. Metabolic control of longevity. Cell. 2016; 166: 802-821https://doi.org/10.1016/j.cell.2016.07.031 Nutrition, longevity and disease: from molecular mechanisms to interventions. Cell. 2022; 185: 1455-1470https://doi.org/10.1016/j.cell.2022.04.002 López-Otín C. Blasco M.A. Partridge L. Serrano M. Kroemer G. Hallmarks of aging: An expanding universe. Cell.
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