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Susan Rosser

As seen in: Nature, The Guardian, Wiley Online Library, ACS Publications, BioRxiv, Financial News, Idaho Statesman, Lexology, Mondaq
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Articles

Synthetic super-enhancers enable precision viral immunotherapy

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By Ute Koeber, Mantas Matjusaitis, Neza Alfazema, Katharine Furlong, ZeYu Wang, Zeyu Wang, Rachel White, Alhafidz Hamdan, Pooran S Dewari, Gregoire Morisse, Mariela Navarette, Rosie Willis, Jin Wang, Michelle Clark, Carla de Sousa, Shahida Sheraz, Ben Southgate, Justyna Cholewa-Waclaw, Sabine Gogolok, Gillian Morrison, Felipe Cancino, Faye Robertson, Anna Williams, Susan Rosser, Paul Brennan Verified, Dirk Sieger, Abdenour Soufi, Sergio A Quezada, Steven M. Pollard
| Nature Verified
Abstract Cell-type-specific promoters are used in gene therapy to restrict expression of the therapeutic payload. However, these promoters often have suboptimal strength, selectivity and size. Here, leveraging recent insights into the function of enhancers, we developed synthetic super-enhancers (SSEs) by assembling functionally validated enhancer fragments into multipart arrays.
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Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

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By Kate Meeson, Joanne Watson, Susan Rosser, Ellie Hawke
| Wiley Online Library Verified
FBA flux balance analysis FDBK FUJIFILM Diosynth Biotechnologies, UK FDBKA cell line mAb expressing Apollo X CHO-DG44 cell line FDR false discovery rate FVA flux variability analysis GEM genome-scale model GPR gene–protein-reaction rule mAb monoclonal antibody Qp specific productivity 1 Introduction Unlike other rodent species, such as the house mouse (Mus musculus) or the Norway rat (Rattus norvegicus), the Chinese Hamster (Cricetulus griseus) is not primarily utilised for in vivo testing.
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Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells

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By Kate Meeson, Joanne Watson, Susan Rosser, Ellie Hawke
| Wiley Online Library Verified
FBA flux balance analysis FDBK FUJIFILM Diosynth Biotechnologies, UK FDBKA cell line mAb expressing Apollo X CHO-DG44 cell line FDR false discovery rate FVA flux variability analysis GEM genome-scale model GPR gene–protein-reaction rule mAb monoclonal antibody Qp specific productivity 1 Introduction Unlike other rodent species, such as the house mouse (Mus musculus) or the Norway rat (Rattus norvegicus), the Chinese Hamster (Cricetulus griseus) is not primarily utilised for in vivo testing.
Open in Who Shared Issue with article?
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