Susana P Simmonds

Abstract The liver contains an intricate microstructure that is critical for liver function. Architectural disruption of this spatial structure is pathologic. Unfortunately, 2D histopathology, the gold standard for pathological understanding of many liver diseases, can misrepresent or leave gaps in our understanding of complex 3D structural features.

Nanogel receptors for high isoelectric point protein detection: Influence of electrostatic and covalent polymer-protein interactions An aldehyde acrylate-based functional monomer was incorporated into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins.