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Susivarshini Karthigayan on Muck Rack

Susivarshini Karthigayan

As seen in: Nature
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Articles

Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids

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By Azad Khosh, Nicholas Stansbury, Maria Victoria Bariani, Qiwei Yang, Eloïse Dray, Mazhar Adli, Hortensia Ferrero, Ayman Al-Hendy, Thomas Boyer, Sribalasubashini Muralimanoharan, Ana Corachán, Sierra Hathaway, Susivarshini Karthigayan, Claire Schenken, Robert Schenken
| Nature Verified
Abstract Uterine fibroids (UFs) are the most important benign neoplastic threat to women’s health worldwide, with no long-term noninvasive treatment options currently available. Among known UF driver alterations, somatic mutations in Mediator subunit MED12 are by the far the most prevalent, accounting for up to 80% of these clinically significant lesions.
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