Suying Ding

1 Introduction Colchicine is a natural tricyclic alkaloid originally extracted from plants such as Colchicum autumnale. Since its first isolation and naming by French chemists Pierre Joseph Pelletier and Joseph Bienaimé Caventou in 1820 [1], it has been used in medicine for over a century. Modern clinical applications primarily include the treatment of acute gout, familial Mediterranean fever, and certain inflammatory diseases [2].

Abstract Background: The gut microbiota plays an important role in non-alcoholic fatty liver disease (NAFLD). This study aimed to explore gut microbiota-associated biomarkers for incident NAFLD and evaluate their predictive value, providing preliminary evidence for early risk identification. Methods: From an initial cohort of 1,772 participants, 404 were included in the final analysis, comprising 101 incident NAFLD cases and 303 age-matched controls (1:3).

Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement No data, models, or code were generated or used during the study. All analyses in this review are based on data extracted from cited references. Acknowledgments This research was supported by the project Development of Energetic Wastewater Treatment Technologies for Closed-Loop Production Line Water Systems (Grant no. 2024020056).