Suying Li
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Metabolomic profiling delineates the role of adenosine in oocyte quality and embryonic development
Abstract Metabolic determinants of oocyte quality and embryonic development remain incompletely understood. Here, we profiled metabolites in human cumulus cells (CCs) and follicular fluid (FF), validated in two mouse models, and integrated transcriptomics with receptor blockade to define mechanisms. In human CCs, adenosine was higher in cycles yielding fewer high-quality embryos and discriminated embryo quality (ROC AUC = 0.75). Conversely, FF adenosine was reduced in the same context.
The management of slow ovarian response in PCOS patients and its impact on clinical pregnancy outcomes
Reproductive Medical Center of the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Background: The objective of this study was to assess the trade-off between cycle continuation and cancellation in slow ovarian response (SOR) patients, and to evaluate the impact of SOR on embryo developmental potential and clinical pregnancy outcomes. Methods: A retrospective analysis was performed on 482 patients with PCOS.
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