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Suying Xu

As seen in: Nature, Wiley Online Library, ACS Publications, Royal Society of Chemistry
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Articles

Blocking ubiquitination of hnRNPA1 maintains the self-renewal of breast cancer stem cells via mutually exclusive splicing of PKM pre-mRNA

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By Xuemei Lv, Xiaoyu Sun, Suying Xu, Yuanyuan Yan, Shuqi Zhou, Yangyang Zhang, Jiaqi Wang, Jia Liu, Haishan Zhao, Weifan Yao, Ruixin Xiao, Qi Wang, Jianan Xu, Lang Gong, Minjie Wei, Bo Chen, Miao He, Wei-Wei Tong, Dikang Zhang
| Nature Verified
Abstract PKM serves as a rate-limiting enzyme in glycolysis, which produces two isoforms depending on the inclusion of either exon 9 (PKM1) or exon 10 (PKM2). The M2 pyruvate kinase (PKM2) isoform is commonly upregulated in various cancers, where it plays a pivotal role in regulating Warburg effect. Breast cancer stem cells (BCSCs) exhibit enhanced glycolysis, which is crucial for their self-renewal. However, the specific role of PKM2 in BCSCs remains largely unexplored.
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Enzyme Catalysis Induced Nanocluster Assembly into Micrometer-Size Monolayered Nanosheets with Enhanced Near-Infrared Region II Emission Click to copy article link Article link copied!

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By Weilu Xu, Ruxin Feng, Suying Xu
| ACS Publications
Cite Jump to ExpandCollapse ArticleApril 2, 2026 Enzyme Catalysis Induced Nanocluster Assembly into Micrometer-Size Monolayered Nanosheets with Enhanced Near-Infrared Region II Emission Click to copy article linkArticle link copied! Weilu Xu Weilu Xu State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China Ruxin Feng Ruxin Feng State Key Laboratory of Chemical Resource Engineering, College of Chemistry,...
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Enzyme Catalysis Induced Nanocluster Assembly into Micrometer-Size Monolayered Nanosheets with Enhanced Near-Infrared Region II Emission Click to copy article link Article link copied!

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By Weilu Xu, Ruxin Feng, Suying Xu
| dx.doi.org
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