Suzan Omar Mousa

Abstract Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme released in response to the drop in cholesterol level occurring in sepsis. Our study aimed to evaluate the prognostic role of serum Proprotein convertase subtilisin/kexin type 9 (PCSK9) level in children with sepsis and severe sepsis. Sixty children were included in this study.

Loading metrics Open Access Peer-reviewed Research Article Citation: Moness H, Mousa SO, Mousa SO, Adel NM, Ibrahim RA, Hassan EE, et al. (2024) Thrombophilia genetic mutations and their relation to disease severity among patients with COVID-19. PLoS ONE 19(3): e0296668. https://doi.org/10.1371/journal.pone.0296668 Editor: Tai-Heng Chen, Kaohsuing Medical University Hospital, TAIWAN Received: May 20, 2023; Accepted: December 13, 2023; Published: March 20, 2024 Copyright: © 2024 Moness et al.

Abstract OPG/RANK/RANKL axis was reportedly involved in initiating various diseases, especially bone and cardiovascular diseases. This study aimed to assess the relationship between some OPG, RANK, and RANKL polymorphisms and alleles and iron-overload-induced cardiomyopathy in children with transfusion-dependent thalassemia (TDT). This study included 80 TDT children and 80 age and sex-matched controls.