Suzanne Le Reun

Abstract Fast neurotransmission requires the coordinated localization of neurotransmitter receptors opposite presynaptic release sites, which usually relies on the transsynaptic interaction of synaptic adhesion molecules. However, some extracellular proteins have been shown to coordinate pre- and postsynaptic differentiation by more elusive mechanisms.

Abstract The precise localization of postsynaptic receptors opposite neurotransmitter release sites is essential for synaptic function. This alignment relies on adhesion molecules, intracellular scaffolds, and a growing class of extracellular scaffolding proteins. However, how these secreted proteins are retained at synapses remains unclear. We addressed this question using C.