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Sven Marcel Stefan

As seen in: Nature, Wiley Online Library
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Articles

Computer-aided pattern scoring – A multitarget dataset-driven workflow to predict ligands of orphan targets - Scientific Data

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By Katja Stefan, Vigneshwaran Namasivayam, Sven Marcel Stefan
| Nature Verified
Abstract The identification of lead molecules and the exploration of novel pharmacological drug targets are major challenges of medical life sciences today. Genome‐wide association studies, multi-omics, and systems pharmacology steadily reveal new protein networks, extending the known and relevant disease-modifying proteome.
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Medicinal polypharmacology: Exploration and exploitation of the polypharmacolome in modern drug development

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By Sven Marcel Stefan, Muhammad Rafehi, van den Hoorn
| Wiley Online Library Verified
Drug discovery has seen tremendous advancements over the last decades increasingly emphasizing integral strategies for developing clinically effective drugs considering entire (and multiple) pathways rather than individual targets (Morphy & Rankovic, 2007; Proschak et al., 2019; Zimmermann et al., 2007).
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