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Swarali Surendra Lele on Muck Rack

Swarali Surendra Lele

As seen in: The Journal of Immunology
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Articles

Restoration of Follicular T Regulatory/Helper Cell Balance by OX40L-JAG1 Cotreatment Suppresses Lupus Nephritis in NZBWF1/j Mice

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By Prabhakaran Kumar, Sivasangari Balakrishnan, Swarali Surendra Lele, Suman Setty
| The Journal of Immunology Verified
Key Points TFR/TFH cell ratio is impaired during the onset of lupus nephritis in NZBWF1/j mice. OX40L–JAG1 cotreatment expands TFR cells and suppresses TFH cells. Restoration of TFR/TFH balance ameliorates lupus nephritis in NZBWF1/j mice. Abstract Class-switched antinuclear autoantibodies produced by T follicular helper (TFH) cell–dependent germinal center (GC) B cell response play an essential pathogenic role in lupus nephritis (LN).
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Restoration of Follicular T-Regulatory/Helper Cell Balance by OX40L-JAG1 Cotreatment Suppresses Lupus Nephritis in NZBWF1/j Mice

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By Prabhakaran Kumar, Swarali Surendra Lele, Sivasangari Balakrishnan, Suman Setty
| The Journal of Immunology Verified
Prabhakaran Kumar, Sivasangari Balakrishnan, Swarali Surendra Lele, Suman Setty, Shaurya Dhingra, Alan L. Epstein and Bellur S. Prabhakar J Immunol April 25, 2022, ji2200057; DOI: https://doi.org/10.4049/jimmunol.2200057 Key Points TFR/TFH cell ratio is impaired during the onset of lupus nephritis in NZBWF1/j mice. OX40L–JAG1 cotreatment expands TFR cells and suppresses TFH cells. Restoration of TFR/TFH balance ameliorates lupus nephritis in NZBWF1/j mice.
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OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-κB Signaling

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By Prabhakaran Kumar, Swarali Surendra Lele, Vandhana K. Ragothaman, Divya Raghunathan
| The Journal of Immunology Verified
Prabhakaran Kumar, Swarali Surendra Lele, Vandhana K. Ragothaman, Divya Raghunathan, Alan L. Epstein, Shigeru Chiba and Bellur S. Prabhakar J Immunol December 15, 2019, 203 (12) 3225-3236; DOI: https://doi.org/10.4049/jimmunol.1900530 Key Points OX40L-JAG1 induced Treg proliferation mediated via noncanonical NF-κB signaling. OX40L-JAG1 expanded epigenetically stable and suppressive Tregs to ameliorate EAT. OX40L-JAG1 induced TCR-independent selective proliferation of human thymic Tregs.
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