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Articles by Sylvain Simon
Design of sensitive monospecific and bispecific synthetic chimeric T cell receptors for cancer therapy - Nature Cancer
Abstract The adoptive transfer of T cells expressing chimeric antigen receptors (CARs) is effective in B cell malignancies. However, the persistence of cancer cells with low levels or complete absence of the target antigen, thereby evading detection by CAR T cells, leads to relapse. These evasion mechanisms highlight the need for receptors with enhanced sensitivity and multispecificity.
Precise engineering of chimeric antigen receptor expression levels defines T cell identity and function
Abstract Chimeric Antigen Receptor (CAR) T therapy is a potent treatment for haematological malignancies, but T cell exhaustion reduces its efficacy in many patients. Although high CAR transgene levels appear to drive T cell exhaustion, the relationship between CAR expression levels, T cell function, and transcriptional identity is yet to be mapped at high resolution.
Synthetic HLA-independent T cell receptors for cancer immunotherapy
CAR T cells are remarkably effective in hematologic malignancies, but tumor cells expressing low antigen levels can escape elimination. In Nature Medicine, Mansilla-Soto et al. design new chimeric receptors that link the variable regions of antibodies directly to T cell receptor chains and recognize tumor cells with improved antigen sensitivity.
Abstract 4476: PD-1 and TIGIT co-expression identifies a circulating CD8 T cell population predictive of response to anti-PD-1 therapy in melanoma and Merkel-cell carcinoma patients
Immunology Sylvain Simon, Valentin Voillet, Virginie Vignard, Zhong Wu, Camille Dabrowski, Nicolas Jouand, Tiffany Beauvais, Amir Khammari, Cecile Braudeau, Regis Josien, Olivier Adotevi, Caroline Laheurte, Francçois Aubin, Charles Nardin, Samuel Rulli, Raphaël Gottardo, Nirasha Ramchurren, Cheever Martin, Steven P. Fling, Candice D. Church, Paul Nghiem, Brigitte Dreno, Stanley R.
Dual Targeting with CAR T Cells to Limit Antigen Escape in Multiple Myeloma
In The Spotlight Sylvain Simon and Stanley R. Riddell DOI: 10.1158/2643-3230.BCD-20-0122 Published September 2020 Abstract Summary: Adoptive T-cell therapy targeting a single tumor antigen can induce remissions of hematologic cancers but relapses often occur due to the outgrowth of tumor cells with absent or low expression of the antigen. Strategies to simultaneousy target multiple antigens are needed to fully capitalize on the promise of this therapeutic strategy.
Dual Targeting with CAR T Cells to Limit Antigen Escape in Multiple Myeloma
Summary: Adoptive T-cell therapy targeting a single tumor antigen can induce remissions of hematologic cancers but relapses often occur due to the outgrowth of tumor cells with absent or low expression of the antigen. Strategies to simultaneousy target multiple antigens are needed to fully capitalize on the promise of this therapeutic strategy.
Emergence of High-Avidity Melan-A-Specific Clonotypes as a Reflection of Anti-PD-1 Clinical Efficacy
Microenvironment and Immunology Emergence of High-Avidity Melan-A–Specific Clonotypes as a Reflection of Anti–PD-1 Clinical Efficacy Sylvain Simon, Virginie Vignard, Emilie Varey, Tiphaine Parrot, Anne-Chantal Knol, Amir Khammari, Nadine Gervois, Francois Lang, Brigitte Dreno and Nathalie Labarriere
Immunotherapies in transplantation and cancer: 22nd NAT meeting/2nd NAT LabEx IGO joint meeting; 1–2 June 2017, Nantes, France
This 22th edition of the NAT (« Nantes Actualités Transplantation ») annual meeting was co-organized for the second time with the LabEx IGO network (« Immuno-Graft Oncology »). This international meeting was held on 1 and 2 June 2017 in Nantes (Western of France). The topic of this 2-days meeting was “Immunotherapies in transplantation and cancer”. This meeting brought together 17 international invited speakers, young researchers and 220 attendees mainly from Europe and North America.
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