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Sylvie Brailly-Tabard on Muck Rack

Sylvie Brailly-Tabard

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Articles

Lower incidence of fracture after IV bisphosphonates in girls with Rett syndrome and severe bone fragility

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By Perrine Charles, Anne-Sophie Lambert, Anya Rothenbuhler, Sylvie Brailly-Tabard
| PLOS
Of 20 patients studied (age: 12.5 years [6; 39]), 14 were non-ambulatory. The incidence of fracture decreased from 37 fractures in 20 patients, to 1 fracture during or after treatment (follow-up: 3.1 years [1.5; 5]). The spine BMD Z-score improved from -3.2 [-5.6; -0.1] to -2.2 [-3.8; 0.0], p = 0.0006. Most parents reported decreases in chronic pain and 2 patients started to walk. Urinary calcium excretion decreased from 0.7 [0.18; 1.5] to 0.2 [0.03; 0.67] mM/mM of creatinine (p = 0.0001).
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