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Ageing-Related Neurodegeneration and Cognitive Decline
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Is Islet Amyloid Polypeptide indeed expressed in the human brain?
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Is Islet Amyloid Polypeptide indeed expressed in the human brain?
Abstract Aim To study the association between pancreatic islet amyloid polypeptide (IAPP) and Alzheimer’s Disease Neuropathological Change (ADNC) in brain biopsies obtained from subjects with idiopathic Normal Pressure Hydrocephalus (iNPH) and in post-mortem (PM) brain samples obtained from aged individuals. Methods For the immunohistochemical (IHC) analyses, two IAPP antibodies (Abs), monoclonal and polyclonal, and Abs directed toward ADNC were applied.
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