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Articles

Serum sodium levels associate with recovery of kidney function in immune checkpoint inhibitor nephrotoxicity

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By Alain Le Moine, Shoji Saito, SYNLAB Pathology Hannover, SYNLAB Holding Germany
| Frontiers
Introduction Immune checkpoint inhibitors (ICIs) are novel drugs targeting programmed cell death protein 1-ligand 1 (PD-L1, synonym CD274, B7 homolog 1) or its receptor (PD-1, synonym CD 279), and are increasingly used in cancer therapy (1). Allowing T cells to remain an activated state by blocking negative co-stimulatory pathways, ICIs enhance the anti-tumoral immune response.
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