Szeman Ruby Chan on Muck Rack

Szeman Ruby Chan

As seen in: Frontiers
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Articles

Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists

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By de Melo Silva, Mark L. Chiu, Szeman Ruby Chan
| Frontiers
Introduction The tumor necrosis factor (TNF) superfamily (TNFSF) of 19 ligands and 29 receptors serve as critical regulators of human immunity, and modulating the activity of individual receptors and ligands for therapeutic benefit in autoimmunity and cancer has been studied for over 40 years (1–3). Activating, or agonizing, TNF receptors to enhance immunity has proven to be a far more elusive goal than inhibiting TNF receptors.
Open in Who Shared Issue with article?
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By Malachi Griffith, Julie Allen, Obi L. Griffith, Szeman Ruby Chan, Kilannin Krysiak, Zachary Skidmore Verified, Jasreet Hundal, Cora D. Arthur, Daniele Runci, Mattia Bugatti, Alexander P. Miceli, Heather Schmidt, Lee Trani, Krishna-Latha Kanchi
| secure.jbs.elsevierhealth.com
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