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Highlights • MT acetylation near the MTOC from stage 1 cells spread out to growing axons (stage 3) • MT acetylation in soma at stage 1 is significantly lower compared with stage 2 neurons • Centrosomal protein, Cep120, modulates axon formation through MT acetylation • TACC3, an MT-stabilizing protein, is enriched in the longest neurites at stages 2 and 3 Summary Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon.
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