Taejeong Bae

Abstract Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing the genome of her children and their father, we analyze the transmission of early pre-gastrulation lineages and corresponding mutations across human generations.

Abstract Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing the genome of her children and their father, we analyzed the transmission of early pre-gastrulation lineages and corresponding mutations across human generations.

Article Dans Une Revue Nature Genetics Année : 2023 Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development Mots clés somatic migration excitation 6. Extended Data items: 10. Suppl Tables: 9 epilepsy focal cortical dysplasia brain mosaicism mTOR single-cell sequencing whole-exome sequencing somatic migration excitation 6. Extended Data items: 10.