Tahmida Sharmin

Conflicts of Interest The authors declare no conflicts of interest that could be interpreted as conflicting with the research presented in this manuscript. Nicholas J. Ashton has served as a consultant for Quanterix and has given lectures in symposia sponsored by Lilly, Quanterix and Biogen.

1 INTRODUCTION Given a multifactorial disorder, Alzheimer's disease (AD) pathogenesis involves dysregulation in diverse biochemical processes (Dorszewska et al., 2016; Koutsodendris et al., 2022; López-Ortiz et al., 2021), including abnormal amyloid-β (Aβ) production and impaired Aβ clearance, tau hyperphosphorylation, insufficiency in brain glucose utilisation, mitochondrial dysfunction, lipid dyshomeostasis, oxidative stress, neuroinflammation and neurotransmitter dyshomeostasis (Toledo et...