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Tai-Ying Chu on Muck Rack

Tai-Ying Chu

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Articles

GPR97 triggers inflammatory processes in human neutrophils via a macromolecular complex upstream of PAR2 activation - Nature Communications

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By Tse-Ching Chen, Kamel El Omari, Alan D. Salama, Elena Seiradake, Tai-Ying Chu, Céline Zheng-Gérard
| Nature Verified
Abstract Neutrophils play essential anti-microbial and inflammatory roles in host defense, however, their activities require tight regulation as dysfunction often leads to detrimental inflammatory and autoimmune diseases. Here we show that the adhesion molecule GPR97 allosterically activates CD177-associated membrane proteinase 3 (mPR3), and in conjugation with several protein interaction partners leads to neutrophil activation in humans.
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