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Taichi Shiobara

As seen in: Respiratory Research
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Articles

Dysregulated metabolic pathways of pulmonary fibrosis and the lipids associated with the effects of nintedanib therapy - Respiratory Research

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By Yasuo Shimizu, Yasuhiro Horibata, Yusuke Nakamura, Ryo Arai, Nobuhiko Uchida, Rinna Tei, Hiroko Morita, Mariko Domae, Tatsuya Yokoyama, Taichi Shiobara, Akihiro Takemasa, Ryosuke Koike, Meitetsu Masawa, Taiji Watanabe, Masaaki Miyoshi
| Respiratory Research Verified
Circulating lipid levels were found to significantly differ between PF patients and HC subjects. The glycerophospholipid metabolism, sphingolipid metabolism, and ether lipid metabolism pathways were altered in PF. Among the lipids involved in glycerophospholipid metabolism, pathways responsible for the synthesis and degradation of LPC, LPE, and LPA were suggested to be dysregulated, and the levels of these lipids were lower in the PF group than in the HC group.
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