Taiko Kim To on Muck Rack

Taiko Kim To

As seen in: Nature
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Articles

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis

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By Shoko Oda Verified, Shumpei Takeuchi, Akihisa Osakabe, Frédéric Berger, Tetsuji Kakutani, Taiko Kim To, Sayaka Tominaga, Akira Kawabe
| Nature Verified
Abstract Heterochromatin formation is pivotal in many eukaryotes with repetitive sequences, such as transposable elements (TEs). However, in plants, where the known de novo DNA methylation mechanism (RdDM) targets euchromatin, how heterochromatin is formed in a region-specific manner remains unclear. We previously reported an RdDM-independent de novo establishment of H3K9me and non-CpG methylation, both of which localize in heterochromatin.
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RNA interference-independent reprogramming of DNA methylation in Arabidopsis

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By Atsushi Toyoda, Frédéric Berger, Taiko Kim To, Tetsuji Kakutani
| Nature Verified
Abstract DNA methylation is important for silencing transposable elements (TEs) in diverse eukaryotes, including plants. In plant genomes, TEs are silenced by methylation of histone H3 lysine 9 (H3K9) and cytosines in both CG and non-CG contexts. The role of RNA interference (RNAi) in establishing TE-specific silent marks has been extensively studied, but the importance of RNAi-independent pathways remains largely unexplored.
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