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Takano Susumu on Muck Rack

Takano Susumu

As seen in: Nature
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Articles

Tie2-enriched nucleus pulposus cell transplantation enables severity-independent disc repair in a canine model with induced and controlled disc degeneration severity

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By Jordy Schol, Takayuki Warita, Shota Tamagawa, Shota Ogasawara, Takafumi Konishi, Masato Sato, Masahiko Watanabe, Daisuke Sakai, Erika Matsushita, Takano Susumu, Asami Kawachi
| Nature Verified
Abstract Intervertebral disc (IVD) degeneration is characterized by extracellular matrix loss, impaired nucleus pulposus cell (NPC) function, and depletion of Tie2-positive NP progenitor cells, leading to progressive structural failure and potential pain. Although cell-based therapies are promising, their regenerative efficacy across different degeneration severities remains unclear.
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