Takehiko Yamanashi on Muck Rack

Takehiko Yamanashi

As seen in: Nature
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Articles

Postoperative delirium in hip fracture patients linked to epigenetic alterations in inflammatory and immune pathways: a genome-wide DNA methylation study

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By Tomoteru Seki, Shota Nishitani, Kyosuke Yamanishi, Akiyoshi Shimura, Tsuyoshi Nishiguchi, Takaya Ishii, Therese Santiago, Nathan Phuong, Nipun Gorantla, Hieu Nguyen, Hiếu Nguyễn, Ryo Takeda, Takeshi Inoue, Daisuke Sugiyama, Kenichi Ueda, Takehiko Yamanashi, Yoshitaka Nishizawa, Bun Aoyama, Takashi Kameoka
| Nature
Abstract Delirium is a common yet underdiagnosed condition in elderly hospitalized patients. The lack of effective diagnostic and therapeutic methods can be attributed to the limited understanding of its pathophysiology. Delirium has recently been reported to be linked to neuroinflammation and epigenetic changes. The aim of this study was to validate the pathways in a larger cohort with a uniform type of surgery, while rigorously adjusting for potential covariates.
Open in Who Shared Issue with article?

Oral administration of MCT oil reduces anxiety-like behavior and is associated with differences in serum BDNF responses in a rat model of PTSD

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By Daisuke Yoshioka, Koji Komatsu, Kaori Adachi, Tsuyoshi Nishiguchi, Masaaki Iwata, Takehiko Yamanashi, Naofumi Kajitani, Chika Ushida, Miyu Matsumi, Moyu Nakamoto, Ryoichi Matsuo, Akihiko Miura
| Nature
Abstract Post-traumatic stress disorder (PTSD) is characterized by neuroinflammatory and neurotrophic dysregulation, and effective interventions remain limited. Medium-chain triglyceride (MCT) oil, a dietary source of ketone bodies, may offer a practical means to elevate circulating β-hydroxybutyrate (BHB), a molecule with reported anti-inflammatory and neuroprotective properties.
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