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Tal Barkai on Muck Rack

Tal Barkai

As seen in: Nature, BioRxiv
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Articles

Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics

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By Roy Novoselsky, Ofra Golani, Tal Barkai, Merav Kedmi, Inna Goliand, Ilan Kent, Ido Nachmany, Shalev Itzkovitz, Michal Fine
| Nature Verified
Abstract Subcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation. However, methods for high-throughput mapping of mRNA localization within intact tissue sections remain limited. Here, we apply high-resolution spatial transcriptomics to systematically resolve intracellular mRNA localization across diverse mammalian tissues.
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A spatial atlas of the healthy human liver from live donors

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By Oran Yakubovsky, Keren Bahar Halpern, Sapir Shir, Roy Novoselsky, Amichay Afriat, Adi Egozi, Tal Barkai, Yotam Harnik, Rouven Hoefflin, Yael Korem Kohanim, Ofra Golani, Inna Goliand, Yoseph Addadi, Merav Kedmi, Hadas Keren-Shaul, Liat Fellus-Alyagor, Dana Hirsch, Chen Mayer, Ron Pery, Niv Pencovich, Timucin Taner, Ido Nachmany, Shalev Itzkovitz, Lena Prichislov
| Nature Verified
Abstract Reconstructing gene expression atlases for human tissues is challenging due to limited access to healthy samples from live individuals. Neurologically deceased donors often show ischaemic changes, and tissues near diseased regions may have altered gene expression1,2. The liver, with its unique regenerative capacity, allows analysis from live healthy donors.
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Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics

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By Roy Novoselsky, Ofra Golani, Tal Barkai
| BioRxiv
Abstract Subcellular RNA localization, including nuclear retention and apical-basal compartmentalization in polarized epithelia plays a central role in post-transcriptional regulation. However, methods for high-throughput mapping of mRNA localization within intact tissue sections remain limited. Here, we apply high-resolution spatial transcriptomics (VisiumHD) to systematically resolve intracellular mRNA localization across diverse mammalian tissues.
Open in Who Shared Issue with article?
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