Overall Features of the Designed p53-DNA Complexes The Effect of DNA Shape on Its Interaction with p53 Structures of Consensus and Natural p53 Response Elements with CATG Motifs The role of sequence-dependent DNA structure on its recognition by gene-regulatory proteins has been investigated extensively during the past 30 years since the pioneering studies of high-resolution crystal structures of protein-DNA complexes (e.g., Aggarwal et al., 1988xRecognition of a DNA operator by the repressor...
