Tali Hana Bar-Lev

Open AccessArticle by 1,2, 1,2, 1, 3, 2,4, 2,3 and 1,2,* 1 Hematology Research Laboratory, Hematology Division, Tel-Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel 2 The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6195001, Israel 3 The BMT Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel 4 Hematology Department, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel * Author to whom correspondence should be addressed. Int. J. Mol. Sci.

Kidney development is a complex process involving multiple interacting and transitioning cell types. Drop-seq single-cell technology, which measures gene expression from many thousands of individual cells, has been used to characterize these cellular differentiation changes that underlie organ development. However, the alternative splicing of many genes creates an additional layer of cellular heterogeneity that Drop-seq technology cannot measure.

Kidney development is a complex process involving multiple interacting and transitioning cell types. Drop-seq single-cell technology, which measures gene expression from many thousands of individual cells, has been used to characterize these cellular differentiation changes that underlie organ development. However, the alternative splicing of many genes creates an additional layer of cellular heterogeneity that Drop-seq technology cannot measure.