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Articles by Tamer Hellou
Impact of residual clonal plasma cell proliferation rate after autologous stem cell transplant on outcomes in multiple myeloma
Dear Editor, Multiple myeloma (MM) is characterized by substantial biological heterogeneity, with outcomes influenced by baseline disease characteristics and depth of response to therapy [1]. Measurable residual disease (MRD) has emerged as a powerful post-treatment prognostic marker; however, assessment of residual disease burden does not directly characterize the proliferative behavior of the remaining clonal plasma cells [2].
Chromosome 1q Gain Defines a Plasma Cell–Dominant Adverse-Risk Subtype in AL Amyloidosis With Inferior Long-Term Survival
1 Introduction Immunoglobulin light chain (AL) amyloidosis is a clonal plasma cell disorder, characterized by the production of misfolded monoclonal light chains that deposit as amyloid fibrils in organs, leading to progressive organ dysfunction and death. Unlike multiple myeloma (MM), prognosis in AL amyloidosis is traditionally driven predominantly by the severity of organ involvement rather than by tumor burden alone.
Determinants of Long-Term Benefit From High Dose Melphalan With Autologous Stem Cell Transplant in AL Amyloidosis
Filename Description ajh70371-sup-0001-Supinfo.docxWord 2007 document , 313.8 KB Table S1: Baseline characteristics of non-landmarked population. Table S2: Cox regression analyses for predictors of EFS. Table S3: Cox regression analysis for EFS stratified by receipt of HDM a there were 90 events in the no HDM cohort, and 84 events in the HDM cohort. Figure S1: Flowchart of cohort selection. Figure S2: Overall survival and time to progression before and after 12-month landmark analysis.
Primary Breast MALT Lymphoma: Clinical Features and Outcomes From a Single‐Institution Experience at Mayo Clinic
Filename Description ajh70178-sup-0001-Figures.docxWord 2007 document , 635 KB Figure S1: Survival outcomes stratified by initial treatment modality. (A) Overall survival (OS) and (B) event-free survival (EFS) in patients with primary breast MALT lymphoma, comparing those treated with resection (red) versus radiation (blue). Figure S2: Flowchart illustrating relapse patterns ( = 12) among patients with primary breast MALT lymphoma.
Impact of t(11;14) primary cytogenetic abnormality and the cumulative effect of multiple high-risk cytogenetics at diagnosis on the outcomes of patients with primary plasma cell leukemia | Blood Cancer Journal
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To the Editor: Primary plasma cell leukemia (pPCL) is a rare and aggressive variant of multiple myeloma (MM), marked by elevated clonal plasma cells (PCs) in the peripheral blood, accounting for ~1–2% of new MM cases [1]. Historically, it was defined as ≥20% circulating plasma cells (cPCs) and/or an absolute PC count >2 × 10⁹/L, but the International Myeloma Working Group (IMWG) revised this in 2013 to require only one of these criteria [2].
By Tamer Hellou, Shaji Kumar Verified, Samhar Samer Alouch, Angela Dispenzieri, Dragan Jevremovic, Francis K Buadi, David Dingli, Saurabh Zanwar, Prashant Kapoor, Eli Muchtar, Taxiarchis Kourelis, Joselle M. Cook, Moritz Binder, Nadine Abdallah, Yi Lin, Ronald S. Go, Mustaqeem Siddiqui, Morie A Gertz, S. Vincent Rajkumar
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Nature
Verified
Cancers | Free Full-Text | Low Alanine-Aminotransferase Blood Activity Is Associated with Increased Mortality in Chronic Lymphocytic Leukemia Patients: A Retrospective Cohort Study of 716 Patients
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