Ute Hegenbart

1 Introduction Tissue deposition of misfolded proteins results in a spectrum of rare diseases called amyloidoses. The most common form is systemic light chain AL amyloidosis, which is caused by the generation of free light chains derived from amyloid fibrils produced by a low-grade B-cell or plasma cell clone. AL amyloidosis can affect various organs, most commonly the heart, kidney, liver, nerves, and soft tissue.

Abstract The role of autologous stem cell transplantation (ASCT) is central in AL amyloidosis and continues to be defined in the era of newer therapies. To evaluate contemporary patient selection, practice patterns, and outcomes, we conducted a retrospective, multicenter study across nine tertiary referral centers, including 1047 patients with AL amyloidosis who underwent ASCT between 2010 and 2020.

Filename Description ajh70371-sup-0001-Supinfo.docxWord 2007 document , 313.8 KB Table S1: Baseline characteristics of non-landmarked population. Table S2: Cox regression analyses for predictors of EFS. Table S3: Cox regression analysis for EFS stratified by receipt of HDM a there were 90 events in the no HDM cohort, and 84 events in the HDM cohort. Figure S1: Flowchart of cohort selection. Figure S2: Overall survival and time to progression before and after 12-month landmark analysis.