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Abstract Collagen, a major component of the extracellular matrix, undergoes reorganization during tumorigenesis. However, visualizing collagen in tissue currently requires special stains (complicated by variability) or imaging (hindered by reliability, cost, and throughput). Here, we describe an approach to exhaustively detect and quantify collagen in hematoxylin and eosin (H&E)-stained images.

eLife Assessment This valuable study tests whether prediction error or prediction uncertainty controls how the brain segments continuous experience into events. The paper uses validated models that predict human behavior to analyze multivariate neural pattern changes during naturalistic movie watching. The authors provide solid evidence that there are overlapping but partially distinct brain dynamics for each signal.