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Tan-Ying Zhang

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Articles

In vivo base editing of Chd3 rescues behavioural abnormalities in mice - Nature

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By Wei-Ke Li, Yi-Xiao Geng, Shu-Qian Zhang, Shi-Hao Wu, Yan-Bo Cheng, Jun-Wen Wang, Zhan-Kui Xu, Wen-Xin Wang, Tan-Ying Zhang, Pei-Ye Wang, Yi-Ting Yuan, Juan Fan, Jun Wu, Ruo-Chuan Xu, Yue-Fang Zhang, Gong-Jia Tao, Zheng-Hui Li, Chen-Xi Lin, Tian-Shu Li, Xin-yi Zhang, Jie Li, Ru Zhong Zhang, Wen-Xiu Yang, Jia-Shuo Wen, Zun-Yuan Yang, Wen Zeng, Ai-Lian Du, Jin-Song Li, Tian-Lin Cheng, Zilong Qiu
| Nature Verified
Abstract Neurodevelopmental disorders that arise from de novo mutations in chromatin-remodelling genes lack targeted treatments. Snijders Blok–Campeau syndrome (SNIBCPS)1, which is caused by pathogenic variants in CHD3, manifests with intellectual disability, autistic-like behaviours and motor deficits2. Whether somatic gene correction can reverse such phenotypes in vivo remains unknown.
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