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Tangcong Chen

As seen in: Nature, Wiley Online Library, BioRxiv
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Articles

Metabolic hormone and adipokine alterations in major depressive disorder in relation to the acute-phase inflammatory response and early-life adversity

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By Tangcong Chen, Yueyang Luo, Mengqi Niu, Mengdie Li, Abbas Almulla, Marta Kubera, Yingqian Zhang, Michael Maes
| Nature Verified
Abstract Major depressive disorder (MDD) involves dysregulated neuroimmune, metabolic, and inflammatory pathways. This study characterized metabolic hormone and adipokine profiles in Chinese MDD patients stratified for metabolic syndrome (MetS), and examined associations with depression severity (OSOD), suicidal ideation (SI), illness recurrence (ROI), and physiosomatic symptoms. We enrolled 125 MDD inpatients (age 18–70 years) and 40 healthy controls (age 20–65 years).
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Regulatory T and activated T cells in the chronic unpredictable mild stress mice: sex differences and effects of treatments

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By Mengqi Niu, Yingqian Zhang, Tangcong Chen, Yueyang Luo
| BioRxiv
Abstract Major Depressive Disorder (MDD) is strongly associated with immune dysregulation, which is characterized by excessive T-cell activation and a reduction in regulatory T cells (Tregs), leading to a disruption of immune homeostasis. Pharmacological treatments such as fluoxetine, simvastatin, curcumin, and S-adenosylmethionine (SAMe) have shown promise in alleviating depressive symptoms; however, their precise effects on immune responses remain inadequately understood.
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FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment

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By Mengdie Li, Tangcong Chen, Yueyang Luo, Yingqian Zhang
| BioRxiv
Abstract Background: The demethylase fat mass and obesity-related protein (FTO) is strongly associated with depression. Aging is a risk factor for synaptic plasticity damage in the brain and leads to neurocognitive dysfunctions. However, whether FTO is associated with susceptibility to depression in different age groups remains unknown.
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