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Tania Sluckin C on Muck Rack

Tania Sluckin C

As seen in: EJSO - European Journal of Surgical Oncology
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Articles

Incidence and outcomes of deficient mismatch repair (dMMR) in patients treated for rectal cancer in a national cohort study

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By Eline Van Geffen, Amsterdam UMC, Antonius Ziekenhuis, Cornelis Hogewoning R.C, Regina Beets-Tan G.H, Kees Verhoef, Myriam Chalabi, Miranda Kusters, Sanne-Marije Hazen J.A, Tania Sluckin C, Marilyne Lange M, Peter Snaebjornsson, Corrie Marijnen A.M, Pieter Tanis J, Tjeerd Aukema S
| EJSO - European Journal of Surgical Oncology Verified
Background: In colorectal cancer, 15-20% of the tumours can be subtyped as deficient mismatch repair (dMMR). dMMR cancers in the colon are associated with a poor response to (neo)adjuvant therapy and there is growing interest in personalized treatment with immunotherapy for these specific tumours. In rectal cancer however, dMMR tumours are thought to be rare and distinct clinical features of this group, response to neoadjuvant therapy and oncological outcomes have scarcely been reported.
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