Highlights • Mesoderm and neural crest-derived pericytes (PCs) from hPSCs termed mPCs and ncPCs • mPCs and ncPCs express general and brain-specific pericyte genes • mPCs and ncPCs associate with and promote barrier properties of endothelial cells • WNT is important, but not necessary for neural crest-derived PC specification Summary In the CNS, perivascular cells (“pericytes”) associate with endothelial cells to mediate the formation of tight junctions essential to the function of the...
