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Articles by Tanner Wright
Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells
Abstract Mono-ADP-ribosylation, a modification of both proteins and nucleic acids, is implicated in innate immunity. Intracellularly, this modification is catalyzed by PARP enzymes, some induced in response to interferons. Mono-ADP-ribosylation is reversed by hydrolases including proteins with macrodomains, which are conserved across all kingdoms of life.
"Loss of the Methylarginine Reader Function of SND1 Confers Resistance " by Tanner Wright, Yalong Wang et al.
Abstract Staphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that 'reads' methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5), which is also known to promote tumorigenesis. Although SND1 can drive hepatocellular carcinoma (HCC), it is unclear whether the SND1 Tudor domain is needed to promote HCC.
Rating the Nationals' Uniforms Going Into 2024
The 2023 MLB season has now come to a close which means there is no longer any baseball to watch or write about. While the hot stove and offseason trades are interesting and fun to talk about, I figured I'd take this time to write about something that I probably care way too much about: uniforms. You know the saying "Look good, feel good. Feel good, play good." And I would hope that most fans at least care a little about what their team looks like when they run out on the field.
Can Mike Rizzo and the Nationals Land a Big-Name Free Agent This Winter?
The Nationals had a decent 2023 season showing some potential at points, finishing with a record of 71-91. It is not the greatest, but it is a step in the right direction after losing 107 games in 2022. With the impending rookies likely to be called up at some point in 2024, and the emergence of some young studs already in the big leagues, this raises the question of whether Mike Rizzo should go after some big-name Free Agents to help jumpstart this franchise into a contender once again.
"A STUDY OF THE SND1/PRMT5 AXIS IN LIVER CANCER BY GENETIC MOUSE MODELS" by Tanner Wright and Tanner Wright
Author ORCID Identifier 0000-0002-4547-9663 Document Type Dissertation (PhD) Program Affiliation Genetics and Epigenetics Degree Name Doctor of Philosophy (PhD) Advisor/Committee Chair Mark T. Bedford; PhD Committee Member David G. Johnson, PhD Committee Member Manu M. Sebastian, DVM, PhD Committee Member Min Gyu Lee, PhD Committee Member Taiping Chen, PhD Committee Member Laura Beretta, PhD Hepatocellular Carcinoma, PRMT5, Arginine methylation, SND1, HCC, reader, writer, epigenetics
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