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Tanu Rani Kar on Muck Rack

Tanu Rani Kar

As seen in: Nature
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Articles

Multi-subunit collaboration enables Smc5/6 to function as a composite SUMO E3 complex

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By Xiaoyu Xue, Jiayi Fan, Shibai Li, Xinji Zhu, John Epps, Andrea Romero Verified, Xiaolan Zhao, Sofya Ignatyeva, Patricia Gallegos-Elias, Heather McEntire-Benitez, Tanu Rani Kar, Lillian Eliaz, Kiana Holland
| Nature Verified
Abstract The SUMO E3 enzymes control the efficiency and specificity of protein SUMOylation, providing regulatory means for many cellular processes. While most SUMO E3s fulfill their roles as single proteins, the conserved Nse2 E3 is an obligatory subunit of the genome-protecting complex Smc5/6. How the Smc5/6 complex functions in SUMOylation and the roles of its non-SUMO E3 subunits in this process remain to be elucidated.
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