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As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Articles
A phosphodiesterase-4 inhibitor reduces lung inflammation and fibrosis in a hamster model of SARS-CoV-2 infection
Introduction Coronavirus disease-2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a major global health concern that affected about 770.5 million people and caused 6.9 million deaths worldwide by September 11, 2023 (1).
ADME, Pharmacokinetic Scaling, Pharmacodynamic and Prediction of Human Dose and Regimen of Novel Antiviral Drugs
Abstract : The search for new drugs is an extremely time-consuming and expensive endeavour. Much of that time and money go into generating predictive human pharmacokinetic profiles from preclinical efficacy and safety animal data. These pharmacokinetic profiles are used to prioritize or minimize the attrition at later stages of the drug discovery process.
DS86760016, a Leucyl-tRNA Synthetase Inhibitor with Activity against Pseudomonas aeruginosa
Experimental Therapeutics Manoj Kumar, Madhvi Rao, Kedar P. Purnapatre, Tarani Kanta Barman, Vattan Joshi, Amuliya Kashyap, Tridib Chaira, Ramesh B. Bambal, Manisha Pandya, Souhaila Al Khodor, Dilip J. Upadhyay, Nobuhisa Masuda DOI: 10.1128/AAC.02122-18 ABSTRACT DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage.
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