Tatiana Barichello
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sGC oxidation impairs NO-dependent ophthalmic artery vascular reactivity and alters long-term memory performance in mice
Abstract Nitric oxide (NO)-dependent activation of soluble guanylyl cyclase (sGC) is essential for maintaining cerebrovascular function and cognitive processes. However, sGC is susceptible to oxidative inactivation under vascular and neurodegenerative stress. This study investigated the impact of chronic sGC oxidation on ophthalmic artery (OphA) hemodynamics, brain cGMP signaling, and memory performance in vivo. Young adult C57BL/6 mice were treated for one month with the heme-oxidizing agent ODQ.
Hospital-treated infection associated with Alzheimer’s disease pathology: underlying mechanisms
Abstract Growing epidemiological and mechanistic evidence indicates that infections substantially increase the risk of Alzheimer’s disease (AD) and related dementias. Systemic immune activation and pathogen persistence may act as upstream triggers accelerating neurodegenerative cascades.
Alterations in Gut Microbiome Composition and Increased Inflammatory Markers in Post-COVID-19 Individuals
Faculty, Staff and Student Publications Publication Date 6-1-2025 Journal Molecular Neurobiology DOI 10.1007/s12035-025-04769-w PubMedCentral® Posted Date 6-1-2026 PubMedCentral® Full Text Version Author MSS Abstract Dysfunctions in the immune system and alterations in the microbiome composition following SARS-CoV-2 infection contribute to persistent neurological issues observed in long COVID-19 survivors.
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