Tatou Iseki on Muck Rack

Tatou Iseki

As seen in: MDPI
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Articles

Is Glial Dysfunction the Key Pathogenesis of LRRK2-Linked Parkinson’s Disease?

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By Nobutaka Hattori, Tatou Iseki, Yuzuru Imai
| MDPI
5.2. Role of LRRK2 in Microglia LRRK2 has been implicated in inflammation because LRRK2 gene variants are linked to autoimmune diseases, such as Crohn’s disease and systemic lupus erythematosus [,]. LRRK2 is abundantly expressed in innate immune cells, including monocytes and neutrophils [], where its expression is upregulated by interferon (IFN) γ [,].
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