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Tavi Nathanson

As seen in: PLOS Medicine, Cell Press
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Articles by Tavi Nathanson

Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer

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By Matthew D. Hellmann, Tavi Nathanson, Hira Rizvi, Benjamin C. Creelan
| Cell Press Verified
Genomic and Clinical Characteristics of Study Cohort Are Generalizable Tumor Mutation Burden Is Significantly Associated with Improved Efficacy of Combination Immunotherapy Individual Genes and Additional Molecular Features Associated with Response or Resistance to Combination Immunotherapy Tumor Mutation Burden Is Independent of PD-L1 and Remains Significantly Associated with Efficacy in Multivariable Analysis In patients with advanced cancers treated with PD-1 blockade monotherapy, multiple...
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Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis

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By Alexandra Snyder, Arun Ahuja, Tavi Nathanson, Samuel A. Funt
| PLOS Medicine Verified
These results demonstrate the complex nature of immune response to checkpoint blockade and the compelling need for greater interrogation and data integration of both host and tumor factors. Incorporating these variables in prospective studies will facilitate identification and treatment of resistant patients. Patients with DCB displayed a higher proportion of tumor-infiltrating T lymphocytes (TIL) (n = 24, Mann-Whitney p = 0.047).
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