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Tayah Turocy

As seen in: Nature, Cell Chemical Biology
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Articles

Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism - Nature Chemistry

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By Tayah Turocy, Brianna Duncan-Lowey, Andrew Goodman, Noah W. Palm
| Nature Verified
Abstract Microbiota-mediated drug metabolism can affect pharmacological efficacy. Here we conducted a systematic comparative metabolomics investigation of drug metabolism modes by evaluating the impacts of human gut commensal bacteria on 127 G-protein-coupled receptor (GPCR)-targeted drugs. For the most extensively metabolized drugs in our screen, we elucidated both conventional and unconventional drug transformations and the corresponding activities of generated metabolites.
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Bacterial small molecule metabolites implicated in gastrointestinal cancer development - Nature Reviews Microbiology

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By Tayah Turocy, Jason Crawford
| Nature Verified
Abstract Numerous associations have been identified between cancer and the composition and function of the human microbiome. As cancer remains the second leading global cause of mortality, investigating the carcinogenic contributions of microbiome members could advance our understanding of cancer risk and support potential therapeutic interventions.
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Enterococcus faecalis-derived adenine enhances enterohaemorrhagic Escherichia coli Type 3 Secretion System-dependent virulence - Nature Microbiology

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By Tayah Turocy, Jason Crawford
| Nature Verified
Abstract Interactions between microbiota and enteric pathogens can promote colonization resistance or enhance pathogenesis. The pathobiont Enterococcus faecalis increases enterohaemorrhagic E. coli (EHEC) virulence by upregulating Type 3 Secretion System (T3SS) expression, effector translocation, and attaching and effacing (AE) lesion formation on enterocytes, but the mechanisms underlying this remain unknown.
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